Objective In order to solve the difficult teaching points of medical students'' low willingness to engage in pathology， lack of professional quality and clinical thinking ability.Method Taking the pathology course of Chengdu Medical College as an example， aiming at the needs of the "new medical science" and "Healthy China" strategies for the training of clinical medical talents， ideological and political elements are integrated into the course teaching， and a curriculum system of ideological and political teaching innovation， "three integration， three perspectives， three coordination and three combination"， is built so that the major and the ideological and political education resonance.Result It has cultivated students'' national feelings， medical spirit， empathy ability and doctor-patient communication ability， promoted the cultivation of students'' precision diagnosis and treatment ability， realized the cultivation from theory to practice， from basic to clinical， from single knowledge to practical ability and professional quality， and improved students'' teamwork， communication ability， clinical thinking， medical spirit and innovative practice ability.Conclusion The above curriculum system of ideological and political teaching innovation can effectively improve students'' professional willingness， professional quality and clinical thinking ability in pathology.